March 8, 2012AJP Cell Physiology

Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy

Q: What is the clinical evidence from this study?

Population: Skeletal muscle hypertrophy. Intervention: Mechanical loading (functional overload). Primary outcome: Ribosomal DNA (rDNA) gene transcription and rRNA content.

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Key result

Mechanical loading induced skeletal muscle hypertrophy and increased rRNA synthesis by activating a gene expression program consisting of a Pol I regulon and accessory factors at the rDNA promoter.

Authors

FWFerdinand von WaldenHong Kong Science and Technology Parks Corporation VCVandre CasagrandeUniversidade de São Paulo AFAnn-Kristin Östlund FarrantsStockholm University

Discussion

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Implication

Caution against clinical translation; hypothesis-generating for Pol I regulon in muscle hypertrophy, pending human studies.

PICO

Population

Mice subjected to functional overload of the plantaris to investigate the regulation of ribosomal DNA gene transcription at the onset of skeletal muscle hypertrophy.

Intervention / Comparator

Mechanical loading (functional overload)

Primary Outcome

Ribosomal DNA (rDNA) gene transcription and rRNA content

Cite This Study

Walden et al. (2012) studied Skeletal muscle hypertrophy. Mechanical loading (functional overload) was evaluated on Ribosomal DNA (rDNA) gene transcription and rRNA content. Mechanical loading induced skeletal muscle hypertrophy and increased rRNA synthesis by activating a gene expression program consisting of a Pol I regulon and accessory factors at the rDNA promoter.

synapsesocial.com/papers/6a7ca1bc93373eeacd19087a https://doi.org/10.1152/ajpcell.00460.2011

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Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy

Discussion

Member takes

Implication

PICO

Cite This Study

Mechanical loading induces the expression of a Pol I regulon at the onset of skeletal muscle hypertrophy

Discussion

Member takes

Implication

PICO

Cite This Study

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