Population
Mouse plantaris muscle subjected to mechanical overload
Design
Preclinical
Authors
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Suggests Wnt/beta-catenin involvement in overload hypertrophy; leaves open therapeutic targeting in human muscle disorders.
This study provides the first evidence that the Wnt signaling pathway induces beta-catenin/Lef-1 activation of growth-control genes during overload-induced skeletal muscle hypertrophy.
Armstrong et al. (2005) studied this question.
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