Key result
Intravenous ghrelin significantly inhibited overall autonomic function (total power) across all subjects (P=0.001), with significant effects in healthy controls but not in obese or vagotomized subjects.
Why the study?
Does intravenous ghrelin alter autonomic function in healthy, obese, and vagotomized subjects?
Population
21 subjects including 7 lean, 7 morbidly obese, and 7 post-gastrectomy subjects
Comparison
Intravenous ghrelin (5 pmol/kg/min) over 270 min vs Intravenous saline over 270 min
Design
RCT, Randomized crossover, Double-blinded, placebo-controlled
Follow-up
270 min
Authors
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Ghrelin autonomic suppression is lost in obesity and vagotomy; confirms vagal dependence and extends mechanistic insights for targeted therapies.
RCT (n=21)
Double-blind
Randomized crossover
Does intravenous ghrelin alter autonomic function in healthy, obese, and vagotomized subjects?
p-value: p=0.001
Intravenous ghrelin inhibits sympathetic nervous system activity in healthy individuals, but this effect is lost in obesity and requires an intact vagus nerve.
Huda et al. (2010) conducted an RCT in Healthy, obese, and vagotomized subjects (n=21). Ghrelin vs. Saline was evaluated on Total power (TP) of heart rate variability (p=0.001). Intravenous ghrelin significantly inhibited overall autonomic function (total power) across all subjects (P=0.001), with significant effects in healthy controls but not in obese or vagotomized subjects.
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