This review highlights the physiological role of angiotensin-(1-7) in hydroelectrolyte balance, distinct from the classical actions of angiotensin II.
Should not yet alter management of electrolyte disorders; leaves open targeted trials on angiotensin-(1-7) modulation.
The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.
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Baracho et al. (1997) studied this question.
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