Key result
Mitral ViV replacement reduces mean transmitral gradient by ~10 mmHg for failed bioprosthesis.
Case Report (n=1)
Transseptal valve-in-valve TMVR is an effective therapy for failed surgical mitral bioprostheses, but clinicians must anticipate and promptly manage acute hemodynamic collapse from left-to-right shunting following septal dilation.
May inform high-risk bioprosthetic mitral stenosis management; leaves open need for prospective data on safety and durability.
Transcatheter valve‐in‐valve mitral valve replacement (ViV TMVR) is an established therapeutic alternative for selected patients with symptomatic degeneration of a surgical mitral bioprosthesis and high or prohibitive surgical risk. We present a 75‐year‐old woman with a failed Pericarbon More 29‐mm mitral bioprosthesis and severe prosthetic mitral stenosis, which was resolved with transseptal transcatheter ViV TMVR. Baseline echocardiography showed mitral valve area 0.45 cm 2 by pressure half‐time, mean transmitral gradient 13 mmHg, preserved left ventricular systolic function, estimated systolic pulmonary artery pressure of 55 mmHg, and severe tricuspid regurgitation. ECG‐gated computed tomography was performed for proper procedural planning. During the procedure, after dilation of the interatrial septum, an abrupt left‐to‐right shunt caused hemodynamic compromise. Rapid rescue balloon dilation of the stenotic mitral bioprosthesis and subsequent implantation of a 26‐mm SAPIEN 3 valve restored forward transmitral flow, reduced the interatrial shunt to a minimum, and avoided septal occluder implantation. Postprocedural echocardiography showed a mean transmitral gradient of 3.5 mmHg, no intraprosthetic or paravalvular regurgitation, no LVOT obstruction, and a minimal, hemodynamically insignificant residual shunt. At 6‐month, 12‐month, and 2‐year follow‐ups, the patient remained asymptomatic with stable prosthetic valve function, although the estimated pulmonary artery pressure remained mildly to moderately elevated and tricuspid regurgitation persisted at a moderate degree. Beyond demonstrating the feasibility of valve‐in‐valve TMVR, this case highlights that septal dilation in severe prosthetic mitral stenosis can precipitate abrupt hemodynamic deterioration by creating a clinically significant left‐to‐right interatrial shunt before relief of the mitral obstruction.
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Valkov et al. (2026) conducted a case report in Failed mitral bioprosthesis with severe prosthetic mitral stenosis (n=1). Transcatheter valve-in-valve mitral valve replacement (ViV TMVR) was evaluated on Mean transmitral gradient (mmHg) post-procedure. Transcatheter valve-in-valve mitral replacement reduced the mean transmitral gradient from 13 to 3.5 mmHg in a patient with a failed bioprosthesis, maintaining stable function at 2-year follow-up.
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