Key result
Angiotensin receptor blocker use in hypertensive patients was associated with a decreased risk of incident cancer compared to non-use (HR 0.833; 95% CI 0.775-0.896).
Why the study?
The authors sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients.
Does the use of common antihypertensive drugs, specifically ARBs, affect the risk of incident cancer in treated hypertensive patients?
Cohort (n=70,549)
Yes
Does the use of common antihypertensive drugs, specifically ARBs, affect the risk of incident cancer in treated hypertensive patients?
Hazard Ratio: 0.833 (95% CI 0.775–0.896)
In a large Korean cohort, long-term use of ARBs was independently associated with a reduced risk of incident cancer compared to other antihypertensive drugs.
May link ARB use to lower cancer incidence in hypertensives; leaves open causality and should not yet alter prescribing.
We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-converting enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696-0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775-0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was independently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.
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Cho et al. (2021) conducted a cohort in Hypertension (n=70,549). Angiotensin receptor blockers (ARBs) vs. Individuals not taking ARBs was evaluated on Incident cancer overall (HR 0.833, 95% CI 0.775-0.896). Angiotensin receptor blocker use in hypertensive patients was associated with a decreased risk of incident cancer compared to non-use (HR 0.833; 95% CI 0.775-0.896).
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