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October 15, 2013Proceedings of the National Academy of SciencesOpen Access

Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate

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Authors

ELEric D. LarsonTranslational Therapeutics (United States)JCJoshua R. St. ClairWilmington University WSWhitney SumnerUniversity of California, San Diego

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Implication

Animal models of aged SAN myocytes extend mechanistic insights into iHR decline; human validation needed before clinical relevance.

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Cite This Study

Larson et al. (2013) studied this question.

synapsesocial.com/papers/6a7ca45452489361ef8ce317 https://doi.org/10.1073/pnas.1308477110

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