Key result
Subclinical thyroid dysfunction is linked to ~70% higher left atrial stiffness and impaired reservoir function.
Why the study?
Thyroid hormones significantly influence cardiac and autonomic function, but their impact on left atrial phasic functions, left atrial stiffness index, and heart rate variability in subclinical thyroid dysfunction required investigation.
Does subclinical thyroid dysfunction affect left atrial phasic functions, left atrial stiffness index, and heart rate variability compared to healthy controls?
Cross-Sectional (n=155)
No
Does subclinical thyroid dysfunction affect left atrial phasic functions, left atrial stiffness index, and heart rate variability compared to healthy controls?
Absolute Event Rate: 0.24% vs 0.14%
p-value: p=0.01
Subclinical thyroid dysfunction is associated with impaired left atrial phasic function, increased left atrial stiffness, and autonomic nervous system imbalance.
Subclinical thyroid dysfunction may impair LA phasic function; leaves open clinical relevance and need for prospective validation.
Background Thyroid hormones significantly influence cardiac function due to the high concentration of thyroid receptors in heart muscle tissue, particularly in the myocardium. Thyroid hormone levels affect heart rate variability, which serves as an indicator of how well the cardiac autonomic system is functioning. The walls of the left atrium (LA) contain numerous sympathetic and parasympathetic nerve cells. Our research focused on examining how thyroid disorders affect the LA phasic functions and left atrial stiffness index (LASI) using two-dimensional speckle tracking echocardiography (2D STE), also analyzing heart rate variability (HRV) in individuals with subclinical thyroid dysfunction. Methods Holter monitoring for HRV was done both in frequency and time domains. Conventional two-dimensional transthoracic echo-Doppler study, tissue Doppler imaging (TDI) and 2D STE were executed for each participant included in the study. The LA longitudinal strain and LA stiffness index (LASI) were assessed using 2D STE analysis. Results The study encompassed 155 participants in total and categorized as follows: euthyroid, subclinical hypothyroidism (SCHypo), and subclinical hyperthyroidism (SCHyper). There was a statistically significant decline in the LA reservoir function and increased LASI in the subclinical thyroid disorders, whether hypothyroidism ( p = 0.01) or hyperthyroidism ( p = 0.007). There was a significantly increased low-frequency/high-frequency ratio (LF/HF) and diminished the percentage of adjacent NN intervals differing by more than 50 ms (PNN50) in the subclinical hyperthyroid group. There was a significant correlation between thyroid-stimulating hormone (TSH) and LA reservoir function ( p = 0.001) and LASI ( p = 0.04), also a significant correlation with LF/HF, PNN50% and the square root of the mean of the sum of the squared differences between successive NN intervals (RMSSD). Conclusion Impaired LA phasic function and increased left atrial stiffness index in subclinical thyroid dysfunction. Impaired autonomic nervous system functions in subclinical thyroid dysfunction especially in subclinical hyperthyroidism.
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Hassan et al. (2025) conducted a cross-sectional in Subclinical thyroid dysfunction (n=155). Subclinical thyroid dysfunction vs. Euthyroid controls was evaluated on Left atrial stiffness index (LASI) (p=0.01). Subclinical thyroid dysfunction was associated with a significantly increased left atrial stiffness index (0.24 in hypothyroidism and 0.23 in hyperthyroidism vs 0.14 in controls) and impaired left atrial reservoir function.
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