Key result
Diabetic retinopathy was associated with significantly lower SDNN (101.1 and 100.6 vs 119.8; P<0.05) and deteriorated heart rate turbulence compared to patients without retinopathy.
Why the study?
To evaluate cardiac autonomic functions using heart rate turbulence and heart rate variability analysis in individuals with asymptomatic diabetic retinopathy and no obvious heart disease.
Cross-Sectional (n=72)
Answers are grounded in this paper and cite their sources.
Patients with diabetic retinopathy exhibit significant deterioration in cardiac autonomic function, suggesting HRV and HRT could be useful for cardiovascular risk evaluation in this population.
BACKGROUND: The aim of this study was to evaluate the cardiac autonomic functions of individuals with asymptomatic diabetic retinopathy (DR) and no obvious heart disease by heart rate turbulence (HRT) and heart rate variability (HRV) analysis. METHODS: A total of 72 patients with type 2 diabetes mellitus: 20 non-retinopathic (NRDM), 26 non-proliferative retinopathic patients (NPDR) and 26 proliferative retinopathic patients (PDR) were enrolled in this cross-sectional study. RESULTS: The HRV parameters of Standard deviation of NN intervals (SDNN) (119.8±11.7, 101.1±20.2, 100.6±17.04), standard deviation of the average NN intervals (108.3±10.8, 91.2±17.5, 93.6±18.4), SDNN Index (49.5±5.1, 40.1±13.4, 38.6±12.7), Root mean square of successive RR interval differences (28.3±5.1, 22.3±7.5, 26±9.2) and Triangular index (34.4±4.3, 29.7±8.8, 27.3±6.7) were significantly lower in the NPDR and PDR groups than in the NRDM group (for all P<0.05). Also, there was a statistically significant higher Turbulence Onset (-1.80±0.7, -1.1±0.9, -0.43±0.81) and lower Turbulence Slope (8.05±2.59, 5.82±3.39, 4.53±2.07) in HRT parameters in patients in the NPDR and PDR groups than in the NRDM group (P<0.001). CONCLUSIONS: We found that HRV and HRT parameters had a significant deterioration in retinopathic individuals compared to the group without retinopathy. We think that HRV and HRT analysis can have an important role in the evaluation of these patients.
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A 2022 study conducted a cross-sectional in Type 2 diabetes mellitus (n=72). Diabetic retinopathy vs. No retinopathy was evaluated on Heart rate variability (HRV) and heart rate turbulence (HRT) parameters (p=<0.05). Diabetic retinopathy was associated with significantly lower SDNN (101.1 and 100.6 vs 119.8; P<0.05) and deteriorated heart rate turbulence compared to patients without retinopathy.
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