What question did this study set out to answer?

To evaluate the efficacy of a smartphone-delivered digital cognitive behavioral therapy program compared with an active online psychoeducation control for treating generalized anxiety disorder.

December 15, 2025JAMA Network OpenOpen Access

Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder

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Authors

EPE. Marie ParsonsBoston University TBTali M. BallHinge Health JCJenna R. CarlHinge Health

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Implication

Randomized trial demonstrates smartphone cognitive behavioral therapy significantly improves remission in generalized anxiety disorder, highlighting accessible digital mental health care.

Key Points

To evaluate the efficacy of a smartphone-delivered digital cognitive behavioral therapy program compared with an active online psychoeducation control for treating generalized anxiety disorder.
Single-blind, parallel-group, decentralized randomized clinical trial (N=351; NCT05748652) conducted remotely across the United States between March 2023 and February 2024.
Adults aged ≥22 years with current generalized anxiety disorder and GAD-7 scores ≥15 were randomized 1:1 to self-directed smartphone digital cognitive behavioral therapy (n=175) or online psychoeducation (n=176).
Evaluated primary outcomes of clinical remission (blinded evaluator CGI-I scale) and anxiety severity (self-reported GAD-7) at 10 weeks (primary endpoint) and 24 weeks (secondary endpoint).
At 10 weeks, participants receiving digital cognitive behavioral therapy achieved significantly higher remission rates than control (71.0% [103/145] vs 34.6% [54/156]; OR, 4.63; 95% CI, 2.85-7.54; P < .001).
Remission advantages were sustained at 24 weeks for the intervention group versus control (77.7% [115/148] vs 52.0% [78/150]; OR, 3.22; 95% CI, 1.95-5.32; P < .001).
Anxiety symptom reductions on the GAD-7 were significantly greater with digital cognitive behavioral therapy at week 10 (Cohen d, 1.09; 95% CI, 0.81-1.37) and week 24 (Cohen d, 0.96; 95% CI, 0.67-1.24).

Cite This Study

Parsons et al. (2025) studied this question.

synapsesocial.com/papers/6a7ca605c2129568296ee0df https://doi.org/10.1001/jamanetworkopen.2025.48884

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Implication

Randomized trial demonstrates smartphone cognitive behavioral therapy significantly improves remission in generalized anxiety disorder, highlighting accessible digital mental health care.

Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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