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June 25, 2004Journal of VirologyOpen Access

Rotavirus Serotype G9 Strains Belonging to VP7 Gene Phylogenetic Sequence Lineage 1 May Be More Suitable for Serotype G9 Vaccine Candidates than Those Belonging to Lineage 2 or 3

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Population

Nine rotavirus G9 strains isolated in five countries, and hyperimmune guinea pig antisera to eight single…

Comparison

Cross-neutralization using hyperimmune guinea… vs Homotypic lineage viruses

Design

Preclinical

Authors

YHYasutaka HoshinoNational Institute of Infectious DiseasesRJRonald W. JonesGreenlane Clinical CentreJRJerri RossNational Institutes of Health

Discussion

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Implication

Lineage 1 G9 strains merit vaccine candidate priority; animal neutralization data leave open human efficacy and cross-protection.

Structured PICO

P
Population
Nine rotavirus G9 strains (three lineage 1, one lineage 2, five lineage 3) isolated in five countries, and hyperimmune guinea pig antisera to eight single VP7 gene substitution reassortants.
I
Intervention
Cross-neutralization using hyperimmune guinea pig antisera to lineage 1, 2, and 3 viruses
C
Comparator
Homotypic lineage viruses
O
Outcome
VP7 neutralization characteristics (efficiency of neutralization)surrogate

Rotavirus G9 strains belonging to lineage 1 exhibit the broadest neutralization reactivity, making them the most suitable candidates for a G9 rotavirus vaccine.

Cite This Study

Hoshino et al. (2004) studied this question.

synapsesocial.com/papers/6a7ca78c4a4ac2b70e6110b8https://doi.org/10.1128/jvi.78.14.7795-7802.2004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of Serotype G9 Rotavirus Strains Isolated in the United States and India from 1993 to 20012003 · 91 citations
  2. 2Comparison of Enzyme Immunoassay and Reverse Transcriptase PCR for Identification of Serotype G9 Rotaviruses1999 · 32 citations
  3. 3Apparent Re‐Emergence of Serotype G9 in 1995 among Rotaviruses Recovered from Japanese Children Hospitalized with Acute Gastroenteritis2000 · 41 citations
  4. 4Detection and Characterization of Novel Rotavirus Strains in the United States1998 · 175 citations
  5. 5Emergence of G9 P[6] Human Rotaviruses in Argentina: Phylogenetic Relationships among G9 Strains2001 · 56 citations