Key result
Prospective follow-up early after surgery for stage II adrenocortical carcinoma was associated with higher 5-year survival compared to retrospective registration (96% vs. 55%, P<0.05).
Why the study?
Does early prospective follow-up by specialized centers improve survival and reduce recurrence in adult patients with stage II adrenocortical carcinoma compared to retrospective registration?
Population
149 adult patients with stage II adrenocortical carcinoma (ACC)
Comparison
Prospective follow-up early after surgery and… vs Registration with the German ACC registry later…
Design
Cohort
Follow-up
5 years
Authors
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May support specialized follow-up in stage II ACC; challenges retrospective estimates via referral bias and leaves open need for RCTs.
Cohort (n=149)
Yes
Does early prospective follow-up by specialized centers improve survival and reduce recurrence in adult patients with stage II adrenocortical carcinoma compared to retrospective registration?
Absolute Event Rate: 96% vs 55%
p-value: p=<0.05
Early prospective follow-up by specialized centers and use of adjuvant mitotane significantly improve survival and reduce recurrence in stage II adrenocortical carcinoma, highlighting a major referral bias in previous retrospective series.
Faßnacht et al. (2010) conducted a cohort in Stage II adrenocortical carcinoma (ACC) (n=149). Prospective follow-up early after surgery vs. Retrospective registration >4 months after diagnosis was evaluated on 5-year survival (p=<0.05). Prospective follow-up early after surgery for stage II adrenocortical carcinoma was associated with higher 5-year survival compared to retrospective registration (96% vs. 55%, P<0.05).
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