Upregulation of NCX1 in PASMC from IPAH patients enhances Ca2+ entry, contributing to elevated cytosolic Ca2+ and potentially driving pulmonary vasoconstriction and vascular remodeling.
No takes yet. Share an insight, caveat, or question.
NCX1 upregulation may drive IPAH pathology; leaves open therapeutic potential pending human validation.
Zhang et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: