What question did this study set out to answer?

To determine whether primates possess a locomotor control system composed of spinal pattern generators modulated by brain-stem locomotor regions.

December 1, 1981Brain

Locomotor Control in Macaque Monkeys

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Authors

EEE. EidelbergInstituto Nacional de Enfermedades Neoplásicas JWJ.G. WaldenMurphy Oil Corporation (United States)NLNguyen LeIndustrial University of Ho Chi Minh City

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Implication

Animal study demonstrates that walking in macaque monkeys requires supraspinal input rather than autonomous spinal pattern generators, indicating greater cortical dependence than in cats.

Key Points

To determine whether primates possess a locomotor control system composed of spinal pattern generators modulated by brain-stem locomotor regions.
Evaluated spinal stepping responses following complete spinal cord transection or selective sparing of central white matter pathways in young adult macaque monkeys (Macaca fascicularis).
Applied electrical stimulation to the posterior subthalamic region and midbrain tegmentum ventral to the inferior colliculi in thalamic preparations to elicit controlled locomotion.
Complete spinal cord transection prevented the induction of spinal stepping, whereas sparing pathways in the central white matter sector was sufficient to sustain stepping and walking.
Electrical stimulation of the posterior subthalamus or midbrain tegmentum successfully elicited controlled locomotion in thalamic monkeys.
Spinal step generators in macaque monkeys exhibit a substantially stronger dependence on supraspinal inputs than those in cats despite homologous brain-stem control centers.

Cite This Study

Eidelberg et al. (1981) studied this question.

synapsesocial.com/papers/6a7cab8ac9ba99be288ce6a4 https://doi.org/10.1093/brain/104.4.647-a

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Implication

Animal study demonstrates that walking in macaque monkeys requires supraspinal input rather than autonomous spinal pattern generators, indicating greater cortical dependence than in cats.

Locomotor Control in Macaque Monkeys

Discussion

Member takes

Implication

Key Points

Cite This Study

Locomotor Control in Macaque Monkeys

Discussion

Member takes

Implication

Key Points

Cite This Study

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