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June 17, 2011Multiple Sclerosis JournalOpen Access

Anti-Epstein–Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel

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Why the study?

Do elevated pre-onset anti-EBNA antibodies increase the risk of developing multiple sclerosis in US military personnel?

Population

666 US military personnel, including 222 individuals who developed multiple sclerosis and 444 age, sex, and…

Comparison

Elevated Epstein-Barr virus antibody titers vs Lower EBV antibody titers

Design

Case-control

Authors

KMKL MungerHarvard UniversityLLLI LevinWalter Reed Army Institute of ResearchÉOÉJ O’ReillyHarvard University

Discussion

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Implication

Caution against using anti-EBNA titers for MS risk prediction in practice; extends EBV-MS link to pre-onset phase in military cohorts.

Structured PICO

Do elevated pre-onset anti-EBNA antibodies increase the risk of developing multiple sclerosis in US military personnel?

P
Population
666 US military personnel, including 222 individuals who developed multiple sclerosis (MS) and 444 age, sex, and race/ethnicity matched controls.
I
Intervention
Elevated Epstein-Barr virus (EBV) antibody titers (anti-EBNA complex and anti-EBNA-1)
C
Comparator
Lower EBV antibody titers
O
Outcome
Risk of developing multiple sclerosis (MS)hard clinical

Elevated pre-onset anti-EBNA antibodies are strong, robust markers of multiple sclerosis risk, independent of vitamin D levels.

Cite This Study

Munger et al. (2011) studied this question.

synapsesocial.com/papers/6a7cac17076dbfca02ba6051https://doi.org/10.1177/1352458511408991
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Also Consider

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  1. 1Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk2010 · 135 citations
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  4. 4Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysis2006 · 523 citations
  5. 5Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis2010 · 199 citations