What question did this study set out to answer?

To evaluate the prospective associations between multi-year healthy lifestyle trajectories, incident cardiovascular disease, and all-cause mortality.

December 20, 2021Frontiers in Cardiovascular MedicineOpen Access

Associations Between Healthy Lifestyle Trajectories and the Incidence of Cardiovascular Disease With All-Cause Mortality: A Large, Prospective, Chinese Cohort Study

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Why the study?

Lifestyles change across the life course, but no prospective study has examined direct associations between healthy lifestyle trajectories and subsequent cardiovascular disease or all-cause mortality risk.

Does maintaining a high-stable healthy lifestyle trajectory reduce the incidence of cardiovascular disease and all-cause mortality in Chinese adults compared to a low-stable trajectory?

Population

52,248 participants in a Chinese cohort

Comparison

Four distinct healthy lifestyle score trajectories over 6 years

Design

Prospective cohort study

Authors

XDXiong DingHarbin Medical University WFWei FangRenji Hospital XYXiaojie YuanShandong University

Discussion

Member takes

Implication

Lifestyle trajectories may stratify long-term CVD risk; extends prior static studies but leaves open causal effects.

Key Points

To evaluate the prospective associations between multi-year healthy lifestyle trajectories, incident cardiovascular disease, and all-cause mortality.
Prospective cohort analysis of 52,248 participants in China assessing healthy lifestyle scores across three waves (2006–2007, 2008–2009, and 2010–2011).
Latent mixture modeling identified four distinct lifestyle score trajectories over 6 years: low-stable (n=11,248), high-decreasing (n=7,374), low-increasing (n=7,828), and high-stable (n=25,799).
Age-scale Cox proportional hazard regression estimated multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for cardiovascular disease and all-cause mortality.
Compared to the low-stable trajectory, the high-stable trajectory significantly reduced risk for cardiovascular disease (HR, 0.73; 95% CI, 0.65–0.81), stroke (HR, 0.70; 95% CI, 0.62–0.79), and all-cause mortality (HR, 0.89; 95% CI, 0.80–0.99).
Subgroup analyses showed reduced cardiovascular events predominantly in men and participants without diabetes, and reduced mortality in individuals over 60 years.
A low-increasing lifestyle trajectory conferred reduced cardiovascular disease risk only alongside decreased body mass index, and reduced all-cause mortality only alongside stable body mass index.

Structured PICO

Does maintaining a high-stable healthy lifestyle trajectory reduce the incidence of cardiovascular disease and all-cause mortality in Chinese adults compared to a low-stable trajectory?

Population

52,248 Chinese adults from the Kailuan cohort, mean age 52.6 years, 76.2% male. Key exclusions: prior cardiovascular disease diagnosis or missing lifestyle data.

Intervention

High-stable healthy lifestyle trajectory over 6 years (2006-2010)

Comparator

Low-stable healthy lifestyle trajectory over 6 years (2006-2010)

Outcome

Incidence of cardiovascular disease (CVD) and all-cause mortality over an 8-year follow-up periodhard clinical

Maintaining a consistently healthy lifestyle over 6 years is associated with a significantly lower risk of cardiovascular disease and all-cause mortality, particularly when body mass index is decreased or stable.

Cite This Study

Ding et al. (2021) studied this question.

synapsesocial.com/papers/6a7caccda64782d1c66ee737 https://doi.org/10.3389/fcvm.2021.790497

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Associations Between Healthy Lifestyle Trajectories and the Incidence of Cardiovascular Disease With All-Cause Mortality: A Large, Prospective, Chinese Cohort Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Associations Between Healthy Lifestyle Trajectories and the Incidence of Cardiovascular Disease With All-Cause Mortality: A Large, Prospective, Chinese Cohort Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider