Population
Freshly isolated vascular smooth muscle cells loaded with fura 2
Comparison
Changing extracellular free Ca2+ concentration… vs Absence of agonists vs. presence of phenylephrine
Design
Preclinical
Authors
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May refine PKC activation models in vascular cells; leaves open translation to human disease or therapy.
The in situ [Ca2+]i threshold for alpha-PKC translocation in vascular smooth muscle cells is lower than previously reported in vitro, suggesting cooperative interactions from agonist-induced second messengers.
Khalil et al. (1994) studied this question.
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