A general, transition-metal-free, one-pot, domino Michael–S N Ar or Ad N E substitution protocol was devised for spiroannulation of oxindoles with ortho -bromoaryl ynones, β-bromoalkenyl ynones, and β-bromoalkenyl enones in a convenient and efficient manner. As an application, a short synthesis of tetracyclic alkaloid spindomycin B was accomplished.
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Samineni et al. (2017) studied this question.
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