Population
Bovine and rat pulmonary artery smooth muscle cells (SMCs) in culture
Comparison
Serotonin treatment, with or without… vs Untreated controls or control siRNA
Design
Preclinical
Authors
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May promote pulmonary vascular remodeling via fibronectin serotonylation; leaves open transglutaminase inhibition for pulmonary hypertension therapy.
Serotonylation of fibronectin by transglutaminase mediates serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells, highlighting a potential mechanism in the pathogenesis of pulmonary hypertension.
Liu et al. (2010) studied this question.
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