Why the study?
To review current understandings, historic development, the rationale for recent principle changes, and international recommendations regarding antibacterial prophylaxis for infective endocarditis.
This review provides a comprehensive overview of the historical context and current international guidelines regarding antibiotic prophylaxis for infective endocarditis, emphasizing the modern shift towards restricting prophylaxis to highest-risk patients.
Evolving IE prophylaxis guidelines require cautious interpretation; review leaves open optimal ABP strategies for clinicians and future trials.
The presented review highlights current understandings of prophylaxis for infective endocarditis (IE). The historic aspects of the concept development of antibacterial prophylaxis (ABP) for IE, the main approaches and the rationale for changing the principles of ABP in recent years are described. There are detailed clarifications of published international and national recommendations, in particular, of European Society of Cardiology, National Institute for Health and Clinical Excellence, American Heart Association/American College of Cardiology and Japanese Circulation Society. The critical estimation of earlier adopted international guidelines with analysis of influence of partial or absolute ABP restrictions on the incidence of IE and its complications including fatality rate are presented.
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Тарадин et al. (2020) studied this question.
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