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October 1, 2014Journal of Traditional Chinese Medical SciencesOpen Access

After 4 weeks of treatment, the mean changes in the LVEF (13.1 ± 9.78 vs. 7.34 ± 7.40, P < 0.001) were significantly better in the CHM group than in the placebo group.

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Why the study?

Does Chinese herbal medicine improve left ventricular ejection fraction in patients with chronic heart failure?

Population

220 patients with chronic heart failure (CHF)

Comparison

Chinese herbal medicine granules without… vs Placebo granules without decoction added to…

Design

RCT, randomized, double-blind

Follow-up

4 weeks

Authors

LLLiangtao LuoJWJuan WangAHAiqing Han

Discussion

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Overview

Adjunctive Chinese herbal medicine may improve LVEF in chronic HF; extends RCT evidence for integrative approaches.

Structured PICO

Does Chinese herbal medicine improve left ventricular ejection fraction in patients with chronic heart failure?

P
Population
220 patients with chronic heart failure (CHF)
I
Intervention
Chinese herbal medicine (CHM) granules without decoction according to syndrome differentiation added to standard western treatment for 4 weeks
C
Comparator
Placebo granules without decoction added to standard western treatment for 4 weeks
O
Outcome
Change in the left ventricular ejection fraction (LVEF)surrogate

Chinese herbal medicine used as an adjuvant to standard therapy significantly improved LVEF and symptoms in patients with chronic heart failure over a 4-week period.

Cite This Study

Luo et al. (2014) studied this question.

synapsesocial.com/papers/6a7caec0076dbfca02ba60b2https://doi.org/10.1016/j.jtcms.2014.11.010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chinese Herbal Medicine in the Treatment of Chronic Heart Failure: Three-Stage Study Protocol for a Randomized Controlled Trial2015 · 27 citations
  2. 2Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure: a prospective, single-blind, randomized, controlled, and multicenter clinical trial2017 · 20 citations
  3. 3The Effect of Chinese Herbal Medicine on Quality of Life and Exercise Tolerance in Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2018 · 11 citations
  4. 4A Single-Central, Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial Protocol: A Clinical Effect Evaluation Study on the TCM Comprehensive Intervention Program for Chronic Heart Failure2021 · 2 citations
  5. 5Chinese herbal preparations for chronic heart failure2020 · 4 citations