Why the study?
Does the metabolic rate in the middle prefrontal cortex differ between patients with schizophrenia and normal controls during an auditory discrimination task?
Does the metabolic rate in the middle prefrontal cortex differ between patients with schizophrenia and normal controls during an auditory discrimination task?
Schizophrenia is associated with prefrontal metabolic deficits during sustained attention tasks, with one component sensitive to neuroleptic treatment and another unaffected.
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Separates medication-sensitive from persistent prefrontal deficits in schizophrenia; leaves open their role in guiding therapy or trial endpoints.
Cohen et al. (1988) studied this question.
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