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December 1, 2015MedicineOpen Access

Proprotein Convertase Subtilisin/Kexin type 9, C-Reactive Protein, Coronary Severity, and Outcomes in Patients With Stable Coronary Artery Disease

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Population

616 consecutive, nontreated patients with stable coronary artery disease

Design

Cohort

Follow-up

median of 17 months

Authors

JLJian‐Jun LiSun Yat-sen UniversitySLSha LiGeneral / Preventive / LipidsYZYan ZhangCentral South University

Discussion

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Overview

May aid risk stratification in stable CAD; leaves open whether PCSK9 targeting improves outcomes.

Structured PICO

P
Population
616 consecutive, nontreated patients with stable coronary artery disease
O
Outcome
Composite of cardiac death, stroke, myocardial infarction (MI), post-discharge revascularization, or unstable angina (UA)composite

Baseline plasma PCSK9 levels, along with hs-CRP and coronary severity scores, independently predict major adverse cardiovascular events in patients with stable coronary artery disease.

Cite This Study

Li et al. (2015) studied this question.

synapsesocial.com/papers/6a7cb3ff398814c3397ccf67https://doi.org/10.1097/md.0000000000002426
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