Why the study?
Pulsed field ablation uses nonthermal irreversible electroporation and may have effectiveness comparable to traditional catheter ablation while preventing thermally mediated complications.
Does pulsed field ablation improve freedom from arrhythmia recurrence and procedural failure in patients with symptomatic atrial fibrillation refractory to antiarrhythmic drugs?
Population
Patients with paroxysmal (n=150) or persistent (n=150) drug-refractory symptomatic AF
Comparison
Pulsed field ablation (nonrandomized, paired single-arm cohorts)
Design
Prospective, global, multicenter, nonrandomized, paired single-arm study
Follow-up
1 year
Authors
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PFA shows acceptable 1-year outcomes in paroxysmal AF; leaves open confirmation versus thermal ablation in randomized trials.
Does pulsed field ablation improve freedom from arrhythmia recurrence and procedural failure in patients with symptomatic atrial fibrillation refractory to antiarrhythmic drugs?
Pulsed field ablation demonstrates a low rate of safety events and provides effectiveness consistent with established ablation technologies for treating refractory symptomatic atrial fibrillation.
Verma et al. (2023) studied this question.