Why the study?
Pulsed field ablation is a novel modality using electrical fields to ablate cardiac tissue, but limited data exist regarding its feasibility and safety in humans.
Does pulsed field ablation achieve acute pulmonary vein isolation safely in patients with paroxysmal or persistent atrial fibrillation?
Comparison
Pulmonary vein isolation using a novel pulsed field ablation system
Design
First-in-human, prospective, nonrandomized, multicenter pilot study
Follow-up
30 days
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PFA shows early feasibility in AF; leaves open durability, safety, and comparative effectiveness in larger trials.
Does pulsed field ablation achieve acute pulmonary vein isolation safely in patients with paroxysmal or persistent atrial fibrillation?
In this first-in-human study, pulsed field ablation was feasible and safe for achieving acute pulmonary vein isolation in patients with atrial fibrillation, with 100% acute success and no serious adverse events at 30 days.
A 2021 study studied this question.
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