What question did this study set out to answer?

To characterize longitudinal molecular alterations across the host and gut microbiome during active inflammatory bowel disease.

May 29, 2019NatureOpen Access

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

View Full Paper

Ask AI

Bookmark

Authors

JLJason Lloyd‐PriceGoogle (United States)CACesar ArzeArk Therapeutic (United States)AAAshwin N. AnanthakrishnanMaharaja Sayajirao University of Baroda

Discussion

Member takes

Implication

Longitudinal cohort study uncovers gut dysbiosis and molecular disruptions during active inflammatory bowel disease, highlighting key microbial and metabolic drivers of inflammation.

Key Points

To characterize longitudinal molecular alterations across the host and gut microbiome during active inflammatory bowel disease.
Followed 132 subjects for one year across up to 24 time points as part of the Integrative Human Microbiome Project (HMP2/iHMP).
Analyzed 2,965 stool, biopsy, and blood specimens using integrated multi-omic profiling, including microbial transcription, metabolomics, and host serology.
Active disease exhibited functional dysbiosis marked by an expansion of facultative anaerobes at the expense of obligate anaerobes and altered microbial transcription in clostridia.
Periods of disease activity showed heightened temporal variability accompanied by shifts in metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids) and elevated host serum antibodies.

Cite This Study

Lloyd‐Price et al. (2019) studied this question.

synapsesocial.com/papers/6a7cb41165c70251ff7712ad https://doi.org/10.1038/s41586-019-1237-9

View Full Paper

Ask AI

Bookmark

Implication

Longitudinal cohort study uncovers gut dysbiosis and molecular disruptions during active inflammatory bowel disease, highlighting key microbial and metabolic drivers of inflammation.

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider