Population
Recombinant proteins representing adjacent regions of the dystrophin rod (DYS1416 and DYS1030) and F-actin
Design
Preclinical
Authors
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Identifies dystrophin rod domain actin-binding motif; extends cytoskeletal mapping but leaves open relevance to cardiomyopathy models.
A specific basic repeat cluster in the dystrophin rod domain (DYS1416) binds F-actin through electrostatic interactions, suggesting a mechanism for actin cross-linking.
Amann et al. (1998) studied this question.
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