April 23, 2002Proceedings of the National Academy of SciencesOpen Access

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions

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Population

Male New Zealand White rabbits (2-2.5 kg) from which iliac and femoral arteries were isolated.

Comparison

Acetylcholine in the presence of cAMP… vs Control conditions (ACh alone or vehicle).

Design

Preclinical

Authors

TGTudor M. GriffithCardiff University ACAndrew ChaytorUniversity of California, Los Angeles HTHannah J. Taylor

Discussion

Member takes

Implication

cAMP may potentiate EDHF relaxations via gap junctions in conduit arteries; hypothesis-generating and should not yet inform clinical practice.

Structured PICO

Population

Male New Zealand White rabbits (2-2.5 kg) from which iliac and femoral arteries were isolated.

Intervention

Acetylcholine (ACh) in the presence of cAMP modulators (IBMX, 8-bromo-cAMP), adenylyl cyclase inhibitors (2',5'-dideoxyadenosine), or gap junction inhibitors (Gap 27).

Comparator

Control conditions (ACh alone or vehicle).

Outcome

Mechanical relaxations, cAMP and cGMP accumulation, dye transfer, and smooth muscle membrane potential.surrogate

This preclinical study demonstrates that cAMP plays a permissive role in EDHF-type relaxations by enhancing electrotonic signaling via gap junctions in conduit arteries.

Cite This Study

Griffith et al. (2002) studied this question.

synapsesocial.com/papers/6a7cb4b580d29ce2cbfab782 https://doi.org/10.1073/pnas.092089799

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Implication

cAMP may potentiate EDHF relaxations via gap junctions in conduit arteries; hypothesis-generating and should not yet inform clinical practice.

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider