January 1, 2008Thrombosis and Haemostasis
Clinical implications of clopidogrel resistance
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Why the study?
What are the clinical implications of variable response to clopidogrel therapy in patients with coronary artery disease?
Population
Patients with coronary artery disease receiving clopidogrel therapy
Design
Review
Authors
Discussion
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Implication
Clopidogrel hyporesponse may elevate thrombotic risk in CAD; leaves open whether testing-guided adjustments improve outcomes.
Structured PICO
What are the clinical implications of variable response to clopidogrel therapy in patients with coronary artery disease?
P
Population
Patients with coronary artery disease receiving clopidogrel therapy
I
Intervention
Clopidogrel therapy
O
Outcome
Adverse cardiovascular events (thrombotic events)
Despite inter-individual variability in clopidogrel response being linked to thrombotic events, routine platelet function testing and higher maintenance doses are not currently recommended by guidelines.
Cite This Study
Miguel et al. (2008) studied this question.
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