Key result
CAD is linked to significantly lower levels of circulating acylcarnitines and saturated fatty acids.
Why the study?
Are plasma levels of acylcarnitine derivatives associated with the presence of coronary artery disease in patients presenting with dyspnea on exertion?
Observational (n=20)
Are plasma levels of acylcarnitine derivatives associated with the presence of coronary artery disease in patients presenting with dyspnea on exertion?
Answers are grounded in this paper and cite their sources.
Lower plasma levels of short-chain and saturated fatty acids acylcarnitine derivatives are associated with the presence of coronary artery disease, particularly in obese patients.
Coronary artery disease (CAD) is common in patients burdened with metabolic syndrome. Increased risk of cardiovascular disease is associated with abnormal levels of acylated derivates of carnitine. The present study aimed to evaluate the possible association between carnitine derivatives and coronary artery disease, including obese individuals. Twenty consecutive patients presenting with dyspnea on exertion were enrolled in the prospective analysis for metabolomic profiling. They were divided into two groups regarding CAD presence. Six (60%) men and four (40%) women comprised the CAD group assigned as Group 1, while 6 (60%) men and 4 (40%) women with normal coronary arteries on angiograms as Group 2. Compared to the non-CAD group, the CAD group was characterized by lower levels of the sum of long-chain ACs (p = 0.024), the sum of short-chain ACs (p = 0.022), saturated fatty acids (SFA) (p = 0.030) and monounsaturated fatty acids (MUFA) (p = 0.022). Further subanalysis concerning patients' body mass index and CAD showed significant differences in plasma sum of ACs between the groups (p = 0.050) and SFA (p = 0.050) but not regarding the short-chain ACs (p = 0.060), medium-ACs (p = 0.758), long-chain-ACs (p = 0.141), or MUFA (p = 0.151). Our analysis revealed lower plasma levels of short-chain and saturated fatty acids acylcarnitine derivates in obese patients presenting with CAD.
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Urbanowicz et al. (2025) conducted an observational in Coronary artery disease (n=20). Coronary artery disease vs. Normal coronary arteries was evaluated on Plasma levels of acylcarnitine derivatives and fatty acids (p=0.024). Coronary artery disease was associated with lower levels of long-chain acylcarnitines, short-chain acylcarnitines, and saturated fatty acids compared to non-CAD.
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