What question did this study set out to answer?

To provide a state-of-the-art review summarizing current knowledge of intracellular Wnt-mediated signaling networks and evaluate the traditional binary classification of these pathways.

June 24, 2010Circulation Research

An Updated Overview on Wnt Signaling Pathways

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Authors

MKMichael KühlAlbert Einstein College of Medicine

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Implication

Comprehensive review uncovers complex intracellular Wnt signaling networks across cardiac development, indicating traditional canonical and noncanonical classifications are no longer adequate.

Key Points

To provide a state-of-the-art review summarizing current knowledge of intracellular Wnt-mediated signaling networks and evaluate the traditional binary classification of these pathways.
Narrative synthesis of molecular and cellular studies addressing Wnt growth factor signaling in stem cell differentiation, tissue homeostasis, and cardiovascular physiology.
Analysis of intracellular signal transduction cascades mediated by specific Wnt ligands and Frizzled membrane receptors.
Wnt signaling pathways critically modulate embryogenesis, stem cell maintenance, angiogenesis, cardiac hypertrophy, heart failure, and aging.
The conventional paradigm categorizing Wnt signaling strictly into canonical and noncanonical pathways based solely on ligand or receptor identity is outdated and biologically insufficient.

Cite This Study

Michael Kühl (2010) studied this question.

synapsesocial.com/papers/6a7cbb36076dbfca02ba632e https://doi.org/10.1161/circresaha.110.219840

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Implication

Comprehensive review uncovers complex intracellular Wnt signaling networks across cardiac development, indicating traditional canonical and noncanonical classifications are no longer adequate.

An Updated Overview on Wnt Signaling Pathways

Discussion

Member takes

Implication

Key Points

Cite This Study

An Updated Overview on Wnt Signaling Pathways

Discussion

Member takes

Implication

Key Points

Cite This Study

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