Key result
Higher LV mass/height linked to ~67% higher CHD risk per 50 g/m.
Why the study?
The association between echocardiographically determined left ventricular mass and the incidence of coronary heart disease in an elderly cohort needed to be examined.
Does echocardiographically determined left ventricular mass predict the incidence of coronary heart disease in an elderly cohort?
Cohort (n=1,141)
No
Does echocardiographically determined left ventricular mass predict the incidence of coronary heart disease in an elderly cohort?
Echocardiographic assessment of left ventricular mass provides independent prognostic information for coronary heart disease risk beyond traditional risk factors in the elderly.
Answers are grounded in this paper and cite their sources.
Higher LV mass independently associated with coronary events in elderly; extends Framingham data but leaves open whether measurement alters risk stratification.
Objective To examine the association of echocardiographically determined left ventricular mass with incidence of coronary heart disease in an elderly cohort. Design Cohort study with a follow-up period of 4 years. Setting Population-based. Subjects Elderly original volunteer subjects of the Framingham Heart Study who were free of clinically apparent coronary heart disease. This group included 406 men (mean age, 68 years: range, 60 to 90) and 735 women (mean age, 69 years: range, 59 to 90). Measurements and main results During 4 years of follow-up, coronary heart disease events occurred in 37 men and 33 women. Baseline echocardiographically determined left ventricular mass was associated with incidence of coronary disease in both sexes (P less than 0.01). After adjusting for age, systolic blood pressure, smoking, and the ratio of total/high density lipoprotein cholesterol, the relative risk for a coronary event, per 50 g/m increment in left ventricular mass/height, was 1.67 in men (95% CI, 1.24 to 2.23) and 1.60 in women (95% CI, 1.10 to 2.32). Conclusions Echocardiographic assessment of left ventricular mass offers prognostic information beyond that provided by traditional risk factors, which can improve our ability to identify individuals at high risk for coronary heart disease. These findings may have widespread implications regarding the applications of echocardiography in clinical practice.
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Daniel Levy (1989) conducted a cohort in Coronary heart disease (n=1,141). Left ventricular mass (per 50 g/m increment in left ventricular mass/height) vs. Lower left ventricular mass/height (continuous increment) was evaluated on Incidence of coronary heart disease events (RR 1.67 (men); RR 1.60 (women), 95% CI 1.24-2.23 (men); 1.10-2.32 (women), p=<0.01). Each 50 g/m increment in left ventricular mass/height increased the relative risk of coronary heart disease to 1.67 in men (95% CI, 1.24-2.23) and 1.60 in women (95% CI, 1.10-2.32).
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