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July 1, 1999Blood

Contribution of Distinct Adhesive Interactions to Platelet Aggregation in Flowing Blood

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Authors

ZRZaverio M. RuggeriGeneral / Preventive / LipidsJDJudith DentMedical University of South CarolinaESEnrique Saldı́varCase Western Reserve University

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Implication

May inform targeted antiplatelet strategies; hypothesis-generating for clinical translation in arterial thrombosis.

Key Points

  • To identify the specific molecular bonds and adhesive interactions that mediate platelet accrual and thrombus formation under dynamic blood flow conditions.
  • Used real-time confocal videomicroscopy to observe the bonding mechanisms linking platelets under hydrodynamic flow.
  • Tracked the activity of distinct adhesion receptors and ligands across changing local shear rates during three-dimensional thrombus development.
  • Glycoprotein (GP) Ibα and von Willebrand factor (vWF) functioned in synergy with αIIbβ3 and fibrinogen to maintain platelet accrual.
  • Adhesive synergy was concentrated at the apex of thrombi, where localized three-dimensional growth produced heightened hemodynamic shear rates.

Cite This Study

Ruggeri et al. (1999) studied this question.

synapsesocial.com/papers/6a7cbfce0ea2707e5228a0d3https://doi.org/10.1182/blood.v94.1.172.413k17_172_178
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules1986 · 174 citations
  2. 2Effects of a novel antiplatelet agent in mural thrombogenesis on collagen-coated glass1988 · 55 citations
  3. 3The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes1992 · 3,733 citations
  4. 4Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets1993 · 273 citations
  5. 5Platelet Physiology and Abnormalities of Platelet Function1975 · 225 citations