Why the study?
Does mitral-valve repair improve survival compared to mitral-valve replacement in patients with mitral-valve prolapse and severe mitral regurgitation?
Does mitral-valve repair improve survival compared to mitral-valve replacement in patients with mitral-valve prolapse and severe mitral regurgitation?
In patients with severe mitral regurgitation due to mitral-valve prolapse, mitral-valve repair is recommended and may offer better survival than replacement, despite the risk of recurrence.
May favor repair over replacement in prolapse; leaves open durability and generalizability for prospective trials.
A 55-year-old man presents with a holosystolic murmur of increasing intensity and is given a diagnosis of mitral-valve prolapse with severe mitral regurgitation. He is asymptomatic but has mildly depressed left ventricular function and mild left ventricular enlargement. Mitral-valve repair is recommended. Mitral-valve repair may result in a better survival rate than mitral-valve replacement, but mitral regurgitation can recur.
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Verma et al. (2009) studied this question.
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