Key result
Synthetic bradykinin lowers arterial pressure, vascular resistance, and venous tone in healthy subjects.
Answers are grounded in this paper and cite their sources.
The effects of intravenous injections of synthetic bradykinin on the vascular dynamics of the forearm were studied in nine normal subjects. A plethysmographic technique was used to measure forearm blood flow and to estimate forearm venous tone. Bradykinin decreased mean systemic arterial pressure, elevated forearm blood flow, and reduced calculated forearm vascular resistance and also venous tone. The venodilatation was preceded by brief venoconstriction which was prevented in five subjects pretreated with the antiadrenergic agent, guanethidine. It is postulated (a) that this venoconstriction is one of the compensatory reflex actions that accompany reduction of systemic arterial pressure, and (b) that the prime effect of bradykinin on both the arterial and the venous beds of the forearm is a direct vasodilatation.
No takes yet. Share an insight, caveat, or question.
Mason et al. (1965) studied Healthy normal subjects (forearm vascular dynamics) (n=9). Intravenous synthetic bradykinin (with or without guanethidine pretreatment) was evaluated on Forearm blood flow, calculated forearm vascular resistance, mean systemic arterial pressure, and forearm venous tone. Intravenous synthetic bradykinin in 9 normal subjects lowered arterial pressure, forearm vascular resistance, and venous tone, while guanethidine prevented initial venoconstriction in 5 subjects.
Synapse has enriched 10 related papers. Consider them for comparative context: