ASHP Therapeutic Guidelines on the Pharmacologic Management of Nausea and Vomiting in Adult and Pediatric Patients Receiving Chemotherapy or Radiation Therapy or Undergoing Surgery

induce nausea and vomiting; however, not all of these agents have the same propensity to induce symptoms.In the absence of antiemetic agents, vincristine is associated with nausea and vomiting in less than 10% of patients while cisplatin induces these symptoms in more than 90% of patients. 1In one study, vomiting occurred in 47 (98%) of 48 patients receiving cisplatin without antiemetic therapy. 4Patients had a median of six emetic episodes in the first 24 hours after administration of cisplatin.Vomiting continued after rescue therapy with antiemetics in 77% of patients during this 24-hour period.