Why the study?
Does concurrent use of proton-pump inhibitors and clopidogrel reduce hospitalizations for gastroduodenal bleeding without increasing serious cardiovascular disease in patients hospitalized for coronary heart disease?
Does concurrent use of proton-pump inhibitors and clopidogrel reduce hospitalizations for gastroduodenal bleeding without increasing serious cardiovascular disease in patients hospitalized for coronary heart disease?
In patients with coronary heart disease treated with clopidogrel, concurrent PPI use significantly reduces gastroduodenal bleeding hospitalizations without a clear increase in serious cardiovascular events.
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May warrant PPI co-prescription to mitigate bleeding in clopidogrel users; leaves open cardiovascular safety confirmation in randomized trials.
Wayne A. Ray (2010) studied this question.
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