Cuff-less and continuous blood pressure measurement based on pulse transit time from carotid and toe photoplethysmograms

Blood pressure (BP) is a vital health parameter that varies throughout the day. As a single reading of high BP may not indicate hypertension, continuous monitoring of BP is usually recommended by medical doctors to confirm the diagnosis of hypertension. In the last few decades, researchers have investigated cuff-less and continuous BP measurements based on pulse transit time (PTT). The main purpose of this research is to develop an autoregressive (ARX) system identification (SI)-based PTT calculation model using two PPG signals acquired from carotid and toe. The signals were recorded from 65 subjects with an age range between 20 and 60 years. The results of the study have been validated in two stages. The first validation comprised the estimated BP from PTT using SI compared to the measured BP using the cuff-based method for all subjects. The results of the estimated BP using the proposed method compared to the measured BP obtained using the standard BP cuff measurement method are highly correlated to both systolic blood pressure (R2 = 0.8132) and diastolic blood pressure (R2 = 0.8357). The second validation consisted of comparing PTT values using system identification to the results of the PTT derived from the ECG–PPG method. The results showed that both methods are highly correlated (R2 = 0.7808), and there is no significant difference between them (p < 0.05) with a slightly better PTT estimation related to DBP in the proposed method. Our results have proven that the PTT obtained from the carotid PPG and toe PPG using the system identification approach yielded SBP and DBP estimations that are consistent with the values of the conventional BP cuff method. The newly proposed method has the advantage of being cuff-less and able to provide continuous BP measurements.