Development of Cellular Magnesium Nano-Analysis in Treatment of Clinical Magnesium Deficiency

A novel technique, using energy dispersive X-ray microanalysis (EXA tm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg 2+] i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg 2+ is found in the intravascular space, serum levels of Mg 2+ give little information about a patient’s overall Mg 2+ status with respect to this essential mineral. Using the EXA tm analysis it has shown been determined that Mg 2+ levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15 Seelig M: Might patients with the chronic fatigue syndrome have latent tetany of magnesium deficiency? J Chron Fatigue Syndr4 :77– 107,1998 . [Google Scholar]]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg 2+] i determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg 2+ deficiency. Examples of the application of EXA tm evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction, and bypass surgery. Standardization of control values were performed at NASA [12 Silver B, Arnaud SB: Application of a novel method to measure intracellular ions as applied to space flight, NASA Technol 2000 Proc, Washington, DC,1990 . [Google Scholar]].