Loss of Cardiac Magnesium in Experimental Heart Failure Prolongs and Destabilizes Repolarization in Dogs
Why the study?
Does experimental heart failure reduce cardiac magnesium and alter cellular repolarization in dogs?
Population
16 mongrel dogs (8 subjected to pacing-induced heart failure, 8 normal controls)
Comparison
Demand ventricular pacing at 250 beats/min for 3… vs Normal dogs serving as controls
Design
Preclinical
Follow-up
3 weeks
Authors
Discussion
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Member takes
Implication
Magnesium depletion may underlie repolarization abnormalities in experimental HF; leaves open whether repletion alters outcomes in patients.
Structured PICO
Does experimental heart failure reduce cardiac magnesium and alter cellular repolarization in dogs?
P
Population
16 mongrel dogs (8 subjected to pacing-induced heart failure, 8 normal controls)
I
Intervention
Demand ventricular pacing (VVI) at 250 beats/min for 3 weeks to induce heart failure
C
Comparator
Normal dogs serving as controls
O
Outcome
Sublingual epithelial magnesium, free cardiac magnesium ([Mg2+]i), and time to 90% repolarization in isolated myocytessurrogate
Experimental heart failure induces significant cardiac magnesium loss, which may contribute to abnormal cellular repolarization.
Cite This Study
Haigney et al. (1998) studied this question.