Key result
Decreased cytosolic free magnesium significantly increased the incidence of triggered activities compared to normal magnesium during beta-adrenergic stimulation (83.3% vs 38.3%, P<0.05).
Why the study?
Does decreased cytosolic free magnesium prolong action potential duration and enhance triggered activity in pig myocytes during beta-adrenergic stimulation?
Population
Left ventricular myocytes isolated from Yorkshire swine
Comparison
Cytosolic free [Mg2+] set at 0.12 mM through… vs Cytosolic free [Mg2+] set at 1.2 mM through…
Design
Preclinical
Authors
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May link low magnesium to HF arrhythmogenesis; hypothesis-generating from animal data, requiring clinical validation.
Does decreased cytosolic free magnesium prolong action potential duration and enhance triggered activity in pig myocytes during beta-adrenergic stimulation?
Absolute Event Rate: 83.3% vs 38.3%
p-value: p=< 0.05
Decreased intracellular magnesium prolongs action potential duration and increases triggered activity during beta-adrenergic stimulation, potentially contributing to arrhythmogenesis in heart failure.
Wei et al. (2002) studied Heart failure (arrhythmogenic substrate) (n=25). Decreased cytosolic free magnesium (LoMg) vs. 1.2 mM (HiMg) was evaluated on Incidence of triggered activities (spontaneous AP, EADs, and DADs) during superfusion with isoproterenol (p=< 0.05). Decreased cytosolic free magnesium significantly increased the incidence of triggered activities compared to normal magnesium during beta-adrenergic stimulation (83.3% vs 38.3%, P<0.05).
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