Population
Isolated guinea pig ventricular myocytes
Comparison
Dialysis with different internal Mg2+… vs Dialysis with nominally zero Mg2+
Design
Preclinical
Authors
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Internal Mg2+ may regulate ventricular Ca2+ currents in mammals; leaves open effects on human electrophysiology.
Cytosolic Mg2+ regulates Ca2+ channel activity in mammalian ventricular cells via steady-state inactivation of the high threshold calcium channel.
Agus et al. (1989) studied this question.
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