Population
Yorkshire pig left ventricular myocytes
Comparison
Low intracellular free magnesium at 0.13 mmol/l… vs High intracellular free magnesium at 1.25 mmol/l…
Design
Preclinical
Authors
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Hypothesis-generating for low intracellular magnesium enhancing NCX in heart failure; human validation required before clinical relevance.
Cytosolic free magnesium modulates the Na/Ca exchange current over a physiologic range, suggesting that reduced intracellular magnesium in heart failure could contribute to enhanced NCX activity.
Shao-kui Wei (2002) studied this question.
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