Why the study?
Does an increase in extracellular magnesium affect excitation, conduction, and contraction in isolated mammalian cardiac muscle?
Population
Isolated mammalian cardiac muscle (ventricular myocytes and papillary muscles from rat and rabbit)
Design
Preclinical
Authors
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May caution magnesium dosing in experimental cardiac models; leaves open translation to intact hearts or patients.
Does an increase in extracellular magnesium affect excitation, conduction, and contraction in isolated mammalian cardiac muscle?
Increased extracellular magnesium reduces myocardial excitability, conduction velocity, and contractility through effects on inward currents and calcium transients.
Hall et al. (1992) studied this question.
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