Population
Mammalian ventricular myocytes (computational ionic-metabolic model)
Design
Preclinical
Authors
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No immediate clinical implications from this model; leaves open Mg2+ effects on human excitation-contraction coupling.
Computational modeling demonstrates that small changes in intracellular free Mg2+ significantly alter cardiac excitation-contraction coupling, primarily through modulation of the sarcoplasmic Ca2+-ATPase pump.
Michailova et al. (2004) studied this question.
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