February 1, 1994CirculationOpen Access

Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure.

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Why the study?

Does intravenous magnesium chloride reduce the frequency of ventricular arrhythmia in patients with symptomatic heart failure?

Population

30 patients with symptomatic heart failure. Exclusions: history of symptomatic ventricular arrhythmia…

Comparison

Intravenous magnesium chloride in 5% dextrose in… vs Placebo (5% dextrose [D5W] in water alone).

Design

RCT, Randomized crossover design, Double-blind, placebo-controlled

Follow-up

24 hours

Authors

CSCarla A. SuetaUniversity of North Carolina at Chapel Hill SCS. W. ClarkeUniversity of North Carolina at Chapel Hill SDS DunlapUniversity of Alabama at Birmingham

Discussion

Member takes

Implication

Supports IV magnesium to suppress ventricular ectopy in symptomatic HF; provides RCT confirmation of antiarrhythmic effect.

Structured PICO

Does intravenous magnesium chloride reduce the frequency of ventricular arrhythmia in patients with symptomatic heart failure?

Population

30 patients with symptomatic heart failure (mean LVEF 23.0 +/- 8.0%). Exclusions: history of symptomatic ventricular arrhythmia, receiving antiarrhythmic agents, calcium channel antagonists, or beta-blockers.

Intervention

Intravenous magnesium chloride in 5% dextrose in water (D5W) given as a bolus of 0.3 mEq/kg over 10 minutes followed by a maintenance infusion of 0.08 mEq/kg per hour for 24 hours.

Comparator

Placebo (5% dextrose [D5W] in water alone).

Outcome

Frequency and severity of ventricular arrhythmia (total ventricular ectopy per hour, couplets per day, and episodes of ventricular tachycardia per day) over 24 hours.surrogate

Acute intravenous magnesium administration significantly reduces the frequency of ventricular arrhythmias in patients with symptomatic heart failure.

Cite This Study

Sueta et al. (1994) studied this question.

synapsesocial.com/papers/6a7cdbfeccf86f44befebf2f https://doi.org/10.1161/01.cir.89.2.660

View Full Paper

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Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of acute magnesium administration on the frequency of ventricular arrhythmia in patients with heart failure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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