What question did this study set out to answer?

To assess whether postoperative intravenous magnesium chloride infusion reduces the incidence of arrhythmias in patients undergoing elective coronary artery revascularization.

January 1, 1993European Journal of Cardio-Thoracic Surgery

Arrhythmia prophylaxis after coronary artery surgery *1A randomised controlled trial of intravenous magnesium chloride

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Why the study?

Does intravenous magnesium chloride reduce the incidence of supraventricular arrhythmias in patients undergoing elective myocardial revascularisation?

Population

130 patients undergoing elective myocardial revascularisation

Comparison

Intravenous infusion containing 50 mmol… vs Placebo infusion during the first 48 hours…

Design

RCT, Randomised

Follow-up

48 hours

Authors

ICIan ColquhounRoyal College of Physicians and Surgeons of Glasgow GBG BERGRoyal Hospital for Children MEM ELFIKYAin Shams University

Discussion

Member takes

Implication

Supports perioperative IV magnesium after elective revascularization; confirms benefit for supraventricular arrhythmia prevention in this RCT.

Key Points

To assess whether postoperative intravenous magnesium chloride infusion reduces the incidence of arrhythmias in patients undergoing elective coronary artery revascularization.
Randomized trial involving 130 patients undergoing elective myocardial revascularisation.
Patients received an intravenous infusion of either 50 mmol magnesium chloride (n = 66) or placebo (n = 64) over the first 48 hours following surgery.
Supraventricular arrhythmias developed in 16.7% (11/66) of patients in the magnesium group versus 37.5% (24/64) in the placebo group (P = 0.013).
Serum magnesium concentrations rose from 0.82 ± 0.05 to 1.2 ± 0.25 mmol/l in the intervention arm and decreased from 0.83 ± 0.06 to 0.79 ± 0.11 mmol/l in the placebo arm.
Ventricular fibrillation occurred in three patients in the magnesium group along with one perioperative death, while three placebo patients developed frequent ventricular ectopics.

Structured PICO

Does intravenous magnesium chloride reduce the incidence of supraventricular arrhythmias in patients undergoing elective myocardial revascularisation?

Population

130 patients undergoing elective myocardial revascularisation

Intervention

Intravenous infusion containing 50 mmol magnesium chloride during the first 48 hours following surgery

Comparator

Placebo infusion during the first 48 hours following surgery

Outcome

Incidence of supraventricular arrhythmiashard clinical

Intravenous magnesium supplementation during the first 48 hours after elective myocardial revascularization significantly reduces the incidence of postoperative supraventricular arrhythmias.

Cite This Study

Colquhoun et al. (1993) studied this question.

synapsesocial.com/papers/6a852f724edd3eca19cf22b6 https://doi.org/10.1016/1010-7940(93)90049-h

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Implication

Supports perioperative IV magnesium after elective revascularization; confirms benefit for supraventricular arrhythmia prevention in this RCT.

Arrhythmia prophylaxis after coronary artery surgery *1A randomised controlled trial of intravenous magnesium chloride

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Arrhythmia prophylaxis after coronary artery surgery *1A randomised controlled trial of intravenous magnesium chloride

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider