What question did this study set out to answer?

To evaluate whether intraoperative intravenous magnesium administration effectively reduces postoperative dysrhythmias, morbidity, and mortality in patients undergoing cardiac surgery.

November 4, 1992JAMA

Magnesium administration and dysrhythmias after cardiac surgery. A placebo-controlled, double-blind, randomized trial

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Why the study?

Does intravenous magnesium chloride reduce postoperative morbidity and mortality, including dysrhythmias, in patients undergoing elective cardiac surgery with cardiopulmonary bypass?

Population

100 patients electively scheduled for cardiac surgery involving cardiopulmonary bypass at a tertiary…

Comparison

Intravenous infusion of magnesium chloride, 2 g… vs Placebo intraoperatively after the termination…

Design

RCT, Randomized, Double-blind, placebo-controlled

Follow-up

Early postoperative period

Authors

MEM. R. England

Discussion

Member takes

Implication

Supports IV magnesium post-CPB to cut arrhythmia risk; extends RCT evidence for perioperative arrhythmia prevention.

Key Points

To evaluate whether intraoperative intravenous magnesium administration effectively reduces postoperative dysrhythmias, morbidity, and mortality in patients undergoing cardiac surgery.
Randomized, double-blind, placebo-controlled trial of 100 elective cardiac surgery patients requiring cardiopulmonary bypass at a tertiary university teaching hospital over a 6-month period.
Patients received an intravenous infusion of either magnesium chloride (2 g; n=50) or placebo (n=50) immediately following discontinuation of cardiopulmonary bypass.
Magnesium-treated patients experienced significantly fewer postoperative ventricular dysrhythmias (8 of 50 [16%]) compared with placebo-treated patients (17 of 50 [34%]; P < .04).
Postoperative normomagnesemic patients had fewer new supraventricular dysrhythmias than hypomagnesemic patients (8 of 48 [17%] vs 19 of 52 [37%]; P < .03).
Magnesium recipients achieved significantly higher postoperative cardiac indices in the intensive care unit (2.8 ± 0.1 vs 2.5 ± 0.1 L/min per m²; P < .02), whereas hypomagnesemia was associated with increased ventricular dysrhythmias (P < .04) and prolonged mechanical ventilation (P < .01).

Structured PICO

Does intravenous magnesium chloride reduce postoperative morbidity and mortality, including dysrhythmias, in patients undergoing elective cardiac surgery with cardiopulmonary bypass?

Population

100 patients electively scheduled for cardiac surgery involving cardiopulmonary bypass at a tertiary acute-care 500-bed university teaching hospital

Intervention

Intravenous infusion of magnesium chloride, 2 g, intraoperatively after the termination of cardiopulmonary bypass

Comparator

Placebo intraoperatively after the termination of cardiopulmonary bypass

Outcome

Postoperative morbidity and mortality (including frequency of postoperative ventricular dysrhythmias)hard clinical

Intravenous magnesium administration after cardiopulmonary bypass significantly reduces postoperative ventricular dysrhythmias and improves early postoperative cardiac index.

Cite This Study

M. R. England (1992) studied this question.

synapsesocial.com/papers/6a880e7f8c7e900eb714bbb0 https://doi.org/10.1001/jama.268.17.2395

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Magnesium administration and dysrhythmias after cardiac surgery. A placebo-controlled, double-blind, randomized trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Magnesium administration and dysrhythmias after cardiac surgery. A placebo-controlled, double-blind, randomized trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider