Key result
Pre-operative oral administration of magnesium for 10 days resulted in no significant difference in spontaneous resumption of cardiac rhythm compared to intra-operative flush infusion.
Why the study?
Does pre-operative oral administration of magnesium improve spontaneous resumption of cardiac rhythm in patients undergoing cardiac surgery with cardiopulmonary bypass compared to intra-operative flush infusion?
Does pre-operative oral administration of magnesium improve spontaneous resumption of cardiac rhythm in patients undergoing cardiac surgery with cardiopulmonary bypass compared to intra-operative flush infusion?
Pre-operative oral magnesium for 10 days provides similar rates of spontaneous resumption of cardiac rhythm compared to intra-operative flush infusion during cardiac surgery, though larger trials are needed to confirm non-inferiority or superiority.
Answers are grounded in this paper and cite their sources.
Pre-operative oral magnesium was associated with similar rhythm resumption rates versus intra-operative infusion; leaves open need for randomized confirmation before practice change.
Evidence is growing that magnesium supplementation in patients undergoing cardiac surgery is beneficial, however the best administration route has not been established. Previously, we showed that intra-operative direct flush infusion of magnesium into the aortic root before reperfusion was effective. The present study compared pre-operative oral administration of magnesium for 10 days with intra-operative flush infusion of magnesium for spontaneous resumption of cardiac rhythm and ventricular fibrillation in patients undergoing cardiac surgery with cardiopulmonary bypass (CBP). The rate of spontaneous resumption of cardiac rhythm, the number of shocks required for defibrillation, the energy required for defibrillation and the occurrence of post-CPB ventricular tachyarrhythmias were not significantly different between the groups. Serum magnesium levels were minimally increased following administration of magnesium but were within the normal range at all times in both groups. Oral administration of magnesium might provide my oprotective effects during cardiac surgery, but larger trials with a greater statistical power need to be carried out in order to show this.
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Bełoğul et al. (2009) studied Cardiac surgery with cardiopulmonary bypass. Pre-operative oral administration of magnesium vs. Intra-operative flush infusion of magnesium was evaluated on Spontaneous resumption of cardiac rhythm. Pre-operative oral administration of magnesium for 10 days resulted in no significant difference in spontaneous resumption of cardiac rhythm compared to intra-operative flush infusion.
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