June 11, 2020Frontiers in PharmacologyOpen Access

Metformin Shortens Prolonged QT Interval in Diabetic Mice by Inhibiting L-Type Calcium Current: A Possible Therapeutic Approach

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Why the study?

To evaluate the effect of metformin on diabetes-induced prolonged QT interval and explore potential ionic mechanisms.

Does metformin reduce prolonged QT interval in diabetic mice?

Population

Streptozotocin-induced diabetic mice and neonatal mouse cardiomyocytes

Comparison

Metformin treatment vs untreated diabetic models

Design

Preclinical animal and cellular experimental study

Follow-up

4 weeks

Authors

HWHui WangUniversity of Massachusetts Chan Medical School CWCao WangKunming Medical University YLYuan LüAffiliated Hospital of Youjiang Medical University for Nationalities

Discussion

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Implication

May support QT monitoring in diabetic patients on metformin; leaves open translation to reduced arrhythmic events in humans.

Structured PICO

Does metformin reduce prolonged QT interval in diabetic mice?

Population

Kunming (KM) mice (20-22 g) with streptozotocin-induced Type 1 diabetes (fasting blood glucose > 11.1 mmol/L) and cultured neonatal mice cardiomyocytes.

Intervention

Metformin 50 mg/kg or 250 mg/kg intragastrically for 4 weeks (in vivo); Metformin 10 mM or 30 mM for 24 hours (in vitro).

Comparator

Equivalent volumes of sterilized distilled water (in vivo DM group); 33 mM D-glucose without metformin (in vitro HG group).

Outcome

QTc interval on surface ECG, action potential duration (APD), and L-type calcium current (ICa-L).surrogate

Metformin shortens the prolonged QT interval in diabetic mice by inhibiting the L-type calcium current, suggesting a potential electrophysiological benefit in diabetic cardiopathy.

Limitations

Further studies are needed to elucidate the mechanism by which metformin influences the L-type calcium channel.
Slight difference in the AP waveform between the mouse left ventricle cardiomyocytes and neonatal mouse cardiomyocytes.

Cite This Study

Wang et al. (2020) studied this question.

synapsesocial.com/papers/6a7cc8674f6c5ab12328aba2 https://doi.org/10.3389/fphar.2020.00614

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Metformin Shortens Prolonged QT Interval in Diabetic Mice by Inhibiting L-Type Calcium Current: A Possible Therapeutic Approach

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Metformin Shortens Prolonged QT Interval in Diabetic Mice by Inhibiting L-Type Calcium Current: A Possible Therapeutic Approach

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider